Publications

2017

Title Authors Jounal
The Loss of GSTM1 Associates with Kidney Failure and Heart Failure. Tin A
Grams ME
Journal of the American Society of Nephrology : JASN
GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the COGENT consortium. Trampush JW
Lencz T
Molecular psychiatry
Cross-tissue integration of genetic and epigenetic data offers insight into autism spectrum disorder. Andrews SV
Fallin MD
Nature communications
Association of Mitochondrial DNA Copy Number With Cardiovascular Disease. Ashar FN
Arking DE
JAMA cardiology
Toward the human cellular microRNAome. McCall MN
Halushka MK
Genome research
Genetic Interactions with Age, Sex, Body Mass Index, and Hypertension in Relation to Atrial Fibrillation: The AFGen Consortium. Weng LC
Lubitz SA
Scientific reports
Moderate Coffee Intake Can Be Part of a Healthy Diet. Guallar E
Zhao D
Annals of internal medicine
Circulating ceruloplasmin, ceruloplasmin-associated genes, and the incidence of atrial fibrillation in the atherosclerosis risk in communities study. Arenas de Larriva AP
Alonso A
International journal of cardiology
Genome-wide association study to identify variants associated with acute severe vaso-occlusive pain in sickle cell anemia. Chaturvedi S
DeBaun MR
Blood
Fifteen Genetic Loci Associated With the Electrocardiographic P Wave. Christophersen IE
Ellinor PT
Circulation. Cardiovascular genetics
Erratum: Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation. Christophersen IE
Ellinor PT
Nature genetics
Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney. Wain LV
Ehret GB
Hypertension (Dallas, Tex. : 1979)
Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders. Weiner DJ
Robinson EB
Nature genetics
Association between mitochondrial DNA copy number and sudden cardiac death: findings from the Atherosclerosis Risk in Communities study (ARIC). Zhang Y
Arking DE
European heart journal
Discovery of novel heart rate-associated loci using the Exome Chip. van den Berg ME
Munroe PB
Human molecular genetics
Stress-Dependent Association Between Polygenic Risk for Schizophrenia and Schizotypal Traits in Young Army Recruits. Hatzimanolis A
Stefanis NC
Schizophrenia bulletin
Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation. Christophersen IE
Ellinor PT
Nature genetics
Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia. Consortium Molecular autism
Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study. Haycock PC
Davey Smith G
JAMA oncology
SOS2 and ACP1 Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function. Li M
Chu AY
Journal of the American Society of Nephrology : JASN
GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the COGENT consortium. Trampush JW
Lencz T
Molecular psychiatry
Genetic Obesity and the Risk of Atrial Fibrillation: Causal Estimates from Mendelian Randomization. Chatterjee NA
Albert CM
Circulation
Exaggerated CpH methylation in the autism-affected brain. Ellis SE
Arking DE
Molecular autism
Usefulness of Maintaining a Normal Electrocardiogram Over Time for Predicting Cardiovascular Health. Soliman EZ
Alonso A
The American journal of cardiology


2016

Title Authors Jounal
Gene-gene Interaction Analyses for Atrial Fibrillation. Lin H
Ellinor PT
Scientific reports
GWAS analysis of handgrip and lower body strength in older adults in the CHARGE consortium. Matteini AM
Murabito JM
Aging cell
Fine-mapping, novel loci identification, and SNP association transferability in a genome-wide association study of QRS duration in African Americans. Evans DS
Sotoodehnia N
Human molecular genetics
The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals. Ehret GB
Munroe PB
Nature genetics
52 Genetic Loci Influencing Myocardial Mass. van der Harst P
de Bakker PIW
Journal of the American College of Cardiology
Whole Exome Sequencing in Atrial Fibrillation. Lubitz SA
Lin H
PLoS genetics
Association between Mitochondrial DNA Copy Number in Peripheral Blood and Incident CKD in the Atherosclerosis Risk in Communities Study. Tin A
Arking DE
Journal of the American Society of Nephrology : JASN
Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels. van Leeuwen EM
van Duijn CM
Journal of medical genetics
Genetic Investigation Into the Differential Risk of Atrial Fibrillation Among Black and White Individuals. Roberts JD
Marcus GM
JAMA cardiology
Investigating the Causal Relationship of C-Reactive Protein with 32 Complex Somatic and Psychiatric Outcomes: A Large-Scale Cross-Consortium Mendelian Randomization Study. Prins BP
Alizadeh BZ
PLoS medicine
Rare coding TTN variants are associated with electrocardiographic QT interval in the general population. Kapoor A
Chakravarti A
Scientific reports
Transcriptome analysis of cortical tissue reveals shared sets of downregulated genes in autism and schizophrenia. Ellis SE
Arking DE
Translational psychiatry
Twenty-eight genetic loci associated with ST-T-wave amplitudes of the electrocardiogram. Verweij N
Van Der Harst P
Human molecular genetics
Impact of genetic variants on the upstream efficacy of renin-angiotensin system inhibitors for the prevention of atrial fibrillation. Roberts JD
Marcus GM
American heart journal
Association of Lipid-Related Genetic Variants with the Incidence of Atrial Fibrillation: The AFGen Consortium. Norby FL
Alonso A
PloS one
Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function. Pattaro C
Fox CS
Nature communications


2015

Title Authors Jounal
Fine mapping the CETP region reveals a common intronic insertion associated to HDL-C. van Leeuwen EM
van Duijn C
NPJ aging and mechanisms of disease
Editorial overview: Molecular and genetic bases of disease: Enter the post-GWAS era. Arking D
Rommens J
Current opinion in genetics & development
Common genetic variation and schizophrenia polygenic risk influence neurocognitive performance in young adulthood. Hatzimanolis A
Avramopoulos D
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
Genetic studies of body mass index yield new insights for obesity biology. Locke AE
Speliotes EK
Nature
New genetic loci link adipose and insulin biology to body fat distribution. Shungin D
Mohlke KL
Nature
Joint analysis of psychiatric disorders increases accuracy of risk prediction for schizophrenia, bipolar disorder, and major depressive disorder. Maier R
Lee SH
American journal of human genetics
Association of mitochondrial DNA levels with frailty and all-cause mortality. Ashar FN
Arking DE
Journal of molecular medicine (Berlin, Germany)
Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways. Consortium Nature neuroscience
Beat-to-beat spatiotemporal variability in the T vector is associated with sudden cardiac death in participants without left ventricular hypertrophy: the Atherosclerosis Risk in Communities (ARIC) Study. Waks JW
Tereshchenko LG
Journal of the American Heart Association


2014

Title Authors Jounal
Genetic diversity is a predictor of mortality in humans. Bihlmeyer NA
Arking DE
BMC genetics
Transcriptome analysis reveals dysregulation of innate immune response genes and neuronal activity-dependent genes in autism. Gupta S
Arking DE
Nature communications
Electrocardiographic deep terminal negativity of the P wave in V(1) and risk of sudden cardiac death: the Atherosclerosis Risk in Communities (ARIC) study. Tereshchenko LG
Soliman EZ
Journal of the American Heart Association
Risk factors for atrial fibrillation in patients with normal versus dilated left atrium (from the Atherosclerosis Risk in Communities Study). Qureshi W
Herrington D
The American journal of cardiology
A common SCN5A variant is associated with PR interval and atrial fibrillation among African Americans. Ilkhanoff L
Sotoodehnia N
Journal of cardiovascular electrophysiology
Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization. Arking DE
Newton-Cheh C
Nature genetics
Novel approach identifies SNPs in SLC2A10 and KCNK9 with evidence for parent-of-origin effect on body mass index. Hoggart CJ
Kutalik Z
PLoS genetics
An enhancer polymorphism at the cardiomyocyte intercalated disc protein NOS1AP locus is a major regulator of the QT interval. Kapoor A
Chakravarti A
American journal of human genetics
Sequencing of SCN5A identifies rare and common variants associated with cardiac conduction: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. Magnani JW
Sotoodehnia N
Circulation. Cardiovascular genetics
Novel genetic markers associate with atrial fibrillation risk in Europeans and Japanese. Lubitz SA
Ellinor PT
Journal of the American College of Cardiology
Common variation in fatty acid metabolic genes and risk of incident sudden cardiac arrest. Lemaitre RN
Siscovick DS
Heart rhythm
Targeted sequencing in candidate genes for atrial fibrillation: the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Targeted Sequencing Study. Lin H
Benjamin EJ
Heart rhythm
Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval. Avery CL
Psaty BM
The pharmacogenomics journal
Novel gene variants predict serum levels of the cytokines IL-18 and IL-1ra in older adults. Matteini AM
Walston JD
Cytokine


2013

Title Authors Jounal
RNA-Seq optimization with eQTL gold standards. Ellis SE
Arking DE
BMC genomics
Defining the contribution of CNTNAP2 to autism susceptibility. Sampath S
Chakravarti A
PloS one
SFARI Gene 2.0: a community-driven knowledgebase for the autism spectrum disorders (ASDs). Abrahams BS
Packer A
Molecular autism
The QT interval and risk of incident atrial fibrillation. Mandyam MC
Marcus GM
Heart rhythm
Association between baseline fetal hemoglobin levels and incidence of severe vaso-occlusive pain episodes in children with sickle cell anemia. Bhatnagar P
Debaun MR
Pediatric blood & cancer
Genome-wide meta-analysis of systolic blood pressure in children with sickle cell disease. Bhatnagar P
Arking DE
PloS one
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Lee SH
Wray NR
Nature genetics
Fast association tests for genes with FAST. Chanda P
Bader JS
PloS one
A Novel Stratification Method in Linkage Studies to Address Inter- and Intra-Family Heterogeneity in Autism. Talebizadeh Z
Hu VW
PloS one
Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. den Hoed M
Loos RJ
Nature genetics
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Consortium Lancet (London, England)
Common genetic variation near the connexin-43 gene is associated with resting heart rate in African Americans: a genome-wide association study of 13,372 participants. Deo R
Whitsel EA
Heart rhythm
Meta-analysis of genome-wide association studies identifies six new Loci for serum calcium concentrations. O'Seaghdha CM
Bochud M
PLoS genetics


2012

Title Authors Jounal
Impact of ancestry and common genetic variants on QT interval in African Americans. Smith JG
Newton-Cheh C
Circulation. Cardiovascular genetics
Novel loci associated with PR interval in a genome-wide association study of 10 African American cohorts. Butler AM
Avery CL
Circulation. Cardiovascular genetics
Meta-analysis of 2040 sickle cell anemia patients: BCL11A and HBS1L-MYB are the major modifiers of HbF in African Americans. Bae HT
Steinberg MH
Blood
Genetic variants in platelet factor 4 modulate inflammatory and platelet activation biomarkers. Bhatnagar P
Fletcher CA
Circulation. Cardiovascular genetics
Validated SNPs for eGFR and their associations with albuminuria. Ellis JW
O'Seaghdha CM
Human molecular genetics
Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations. Okada Y
Tanaka T
Nature genetics
Comprehensive evaluation of imputation performance in African Americans. Chanda P
Arking DE
Journal of human genetics
No interactions between previously associated 2-hour glucose gene variants and physical activity or BMI on 2-hour glucose levels. Scott RA
Langenberg C
Diabetes
Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases. Perry JR
Cauchi S
PLoS genetics
Meta-analysis identifies six new susceptibility loci for atrial fibrillation. Ellinor PT
Kääb S
Nature genetics
Postmortem cardiac tissue maintains gene expression profile even after late harvesting. Gupta S
Arking DE
BMC genomics
The genetics of sudden cardiac death. Arking DE
Sotoodehnia N
Annual review of genomics and human genetics
Fine-mapping and initial characterization of QT interval loci in African Americans. Avery CL
North KE
PLoS genetics
A genome-wide association study of total bilirubin and cholelithiasis risk in sickle cell anemia. Milton JN
Klings ES
PloS one


2011

Title Authors Jounal
The association of genetic variants in interleukin-1 genes with cognition: findings from the cardiovascular health study. Benke KS
Fallin MD
Experimental gerontology
Disruption of p16 and activation of Kras in pancreas increase ductal adenocarcinoma formation and metastasis in vivo. Qiu W
Su GH
Oncotarget
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Chambers JC
Kooner JS
Nature genetics
Large-scale candidate gene analysis in whites and African Americans identifies IL6R polymorphism in relation to atrial fibrillation: the National Heart, Lung, and Blood Institute's Candidate Gene Association Resource (CARe) project. Schnabel RB
Heckbert SR
Circulation. Cardiovascular genetics
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Ehret GB
Johnson T
Nature
Exploring biologically relevant pathways in frailty. Ho YY
Walston J
The journals of gerontology. Series A, Biological sciences and medical sciences
Gene-based tests of association. Huang H
Arking DE
PLoS genetics
Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study. Fox ER
Levy D
Human molecular genetics
Identification of a sudden cardiac death susceptibility locus at 2q24.2 through genome-wide association in European ancestry individuals. Arking DE
Chugh SS
PLoS genetics
Genome-wide association study identifies genetic variants influencing F-cell levels in sickle-cell patients. Bhatnagar P
Keefer JR
Journal of human genetics
CUBN is a gene locus for albuminuria. Böger CA
Kao WH
Journal of the American Society of Nephrology : JASN
A common connexin-40 gene promoter variant affects connexin-40 expression in human atria and is associated with atrial fibrillation. Wirka RC
Smith JD
Circulation. Arrhythmia and electrophysiology


2010

Title Authors Jounal
Multiple genetic loci influence serum urate levels and their relationship with gout and cardiovascular disease risk factors. Yang Q
Coresh J
Circulation. Cardiovascular genetics
Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways. Soranzo N
Meigs JB
Diabetes
Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction. Sotoodehnia N
Arking DE
Nature genetics
Genome-wide association analysis identifies multiple loci related to resting heart rate. Eijgelsheim M
O'Donnell CJ
Human molecular genetics
Independent susceptibility markers for atrial fibrillation on chromosome 4q25. Lubitz SA
Ellinor PT
Circulation
Parent-of-origin effects in autism identified through genome-wide linkage analysis of 16,000 SNPs. Fradin D
Fallin MD
PloS one
Common genetic variants associate with serum phosphorus concentration. Kestenbaum B
Fox CS
Journal of the American Society of Nephrology : JASN
Polymorphisms in the NOS1AP gene modulate QT interval duration and risk of arrhythmias in the long QT syndrome. Tomás M
Priori SG
Journal of the American College of Cardiology
Polymorphisms in the mitochondrial DNA control region and frailty in older adults. Moore AZ
Arking DE
PloS one
New loci associated with kidney function and chronic kidney disease. Köttgen A
Fox CS
Nature genetics
Genome-wide association study identifies GPC5 as a novel genetic locus protective against sudden cardiac arrest. Arking DE
Chugh SS
PloS one
NOS1AP variant associated with incidence of type 2 diabetes in calcium channel blocker users in the Atherosclerosis Risk in Communities (ARIC) study. Chu AY
Kao WH
Diabetologia
Common variants in KCNN3 are associated with lone atrial fibrillation. Ellinor PT
Kääb S
Nature genetics
Genome-wide association study of PR interval. Pfeufer A
Heckbert SR
Nature genetics
A genome-wide association analysis of serum iron concentrations. Tanaka T
Ferrucci L
Blood
Transcobalamin-II variants, decreased vitamin B12 availability and increased risk of frailty. Matteini AM
Fallin MD
The journal of nutrition, health & aging


2009

Title Authors Jounal
A resource for analysis of microRNA expression and function in pancreatic ductal adenocarcinoma cells. Kent OA
Mendell JT
Cancer biology & therapy
A genome-wide linkage and association scan reveals novel loci for autism. Weiss LA
Chakravarti A
Nature
Understanding cardiovascular disease through the lens of genome-wide association studies. Arking DE
Chakravarti A
Trends in genetics : TIG
Drug-sensitized zebrafish screen identifies multiple genes, including GINS3, as regulators of myocardial repolarization. Milan DJ
MacRae CA
Circulation
Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry. Benjamin EJ
Witteman JC
Nature genetics
Common genetic variation near the phospholamban gene is associated with cardiac repolarisation: meta-analysis of three genome-wide association studies. Nolte IM
Jamshidi Y
PloS one
Multiple loci associated with indices of renal function and chronic kidney disease. Köttgen A
Fox CS
Nature genetics
Genome-wide association study of blood pressure and hypertension. Levy D
van Duijn CM
Nature genetics
Genomewide association studies: history, rationale, and prospects for psychiatric disorders. Cichon S
Sullivan PF
The American journal of psychiatry
Common variants at ten loci modulate the QT interval duration in the QTSCD Study. Pfeufer A
Chakravarti A
Nature genetics
Genetic variations in nitric oxide synthase 1 adaptor protein are associated with sudden cardiac death in US white community-based populations. Kao WH
Chakravarti A
Circulation
Hybrids of aneuploid human cancer cells permit complementation of simple and complex cancer defects. Dezentje DA
Kern SE
Cancer biology & therapy
Mitochondrial DNA variants of respiratory complex I that uniquely characterize haplogroup T2 are associated with increased risk of age-related macular degeneration. SanGiovanni JP
Chakravarti A
PloS one
Multiple independent genetic factors at NOS1AP modulate the QT interval in a multi-ethnic population. Arking DE
Chakravarti A
PloS one


2008

Title Authors Jounal
Molecular genetic and biochemical analyses of FGF23 mutations in familial tumoral calcinosis. Garringer HJ
White KE
American journal of physiology. Endocrinology and metabolism
Differences in mtDNA haplogroup distribution among 3 Jewish populations alter susceptibility to T2DM complications. Feder J
Mishmar D
BMC genomics
Validation and extension of an empirical Bayes method for SNP calling on Affymetrix microarrays. Lin S
Irizarry RA
Genome biology
Association between microdeletion and microduplication at 16p11.2 and autism. Weiss LA
Daly MJ
The New England journal of medicine
A common genetic variant in the neurexin superfamily member CNTNAP2 increases familial risk of autism. Arking DE
Chakravarti A
American journal of human genetics
Widespread microRNA repression by Myc contributes to tumorigenesis. Chang TC
Mendell JT
Nature genetics


2007

Title Authors Jounal
Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis. Chang TC
Mendell JT
Molecular cell
Associations between genetic variants in the NOS1AP (CAPON) gene and cardiac repolarization in the old order Amish. Post W
Shuldiner AR
Human heredity


2006

Title Authors Jounal
Relative contribution of genetic and nongenetic modifiers to intestinal obstruction in cystic fibrosis. Blackman SM
Cutting GR
Gastroenterology
Human embryonic stem cells have a unique epigenetic signature. Bibikova M
Fan JB
Genome research
Identifying allelic loss and homozygous deletions in pancreatic cancer without matched normals using high-density single-nucleotide polymorphism arrays. Calhoun ES
Kern SE
Cancer research
From vulnerable plaque to vulnerable patient--Part III: Executive summary of the Screening for Heart Attack Prevention and Education (SHAPE) Task Force report. Naghavi M
Shah PK
The American journal of cardiology
A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarization. Arking DE
Chakravarti A
Nature genetics
Variation in the ciliary neurotrophic factor gene and muscle strength in older Caucasian women. Arking DE
Walston J
Journal of the American Geriatrics Society


2005

Title Authors Jounal
Genomic alterations in cultured human embryonic stem cells. Maitra A
Chakravarti A
Nature genetics
IL-6 gene variation is not associated with increased serum levels of IL-6, muscle, weakness, or frailty in older women. Walston J
Chakravarti A
Experimental gerontology
Association between a functional variant of the KLOTHO gene and high-density lipoprotein cholesterol, blood pressure, stroke, and longevity. Arking DE
Dietz HC
Circulation research


2004

Title Authors Jounal
Genomics in sudden cardiac death. Arking DE
Spooner PM
Circulation research


2003

Title Authors Jounal
KLOTHO allele status and the risk of early-onset occult coronary artery disease. Arking DE
Dietz HC
American journal of human genetics
Dysregulation of TGF-beta activation contributes to pathogenesis in Marfan syndrome. Neptune ER
Dietz HC
Nature genetics


2002

Title Authors Jounal
Neisseria gonorrhoeae strain PID2 simultaneously expresses six chemically related lipooligosaccharide structures. Tong Y
Stein DC
Glycobiology
Association of human aging with a functional variant of klotho. Arking DE
Dietz HC
Proceedings of the National Academy of Sciences of the United States of America


2001

Title Authors Jounal
Analysis of lipooligosaccharide biosynthesis in the Neisseriaceae. Arking D
Stein DC
Journal of bacteriology


1995

Title Authors Jounal
Genetic basis of Neisseria gonorrhoeae lipooligosaccharide antigenic variation. Danaher RJ
Stein DC
Journal of bacteriology